Opioids have been the mainstay for pain relief and palliation over a long period of time.They are commonly abused by drug addicts and such dependence usually imparts severe physiologic Western Top effects on multiple organ systems.The negative impact of opioids on the endocrine system is poorly understood and often underestimated.We describe a pati
Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodomain contributes to reduce viral burden in HIV-1 infected patients
Abstract The ectodomain of gp41 is the target of potent binding and neutralizing antibodies (NAbs) and is being explored in new strategies for antibody-based HIV vaccines.Previous studies have suggested that the W164A-3S (3S) and EC26-2A4 (EC26) peptides located in the gp41 ectodomain may be potential HIV vaccine candidates.We assessed 3S- and EC26
The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells.
Vectors derived from human adenovirus type 5, which typically lack the E1A and E1B genes, induce robust GRAPE SEED EXTRACT innate immune responses that limit their therapeutic efficacy.We reported previously that the E1B 55 kDa protein inhibits expression of a set of cellular genes that is highly enriched for those associated with anti-viral defens
Is Inducible Nitric Oxide Synthase (iNOS) Promising as a New Target Against Pulmonary Hypertension?
Pulmonary hypertension (PH) is a progressive disease characterized by elevated blood pressure in the pulmonary arteries, associated also with inflammation and oxidative stress.Inducible nitric oxide synthase (iNOS) is one of the key mediators of inflammation and immune system activation.Although preclinical studies mostly suggest a detrimental role